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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35,  Peer-reviewed, Open-access Journal

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EVALUATION OF DISEASE ACTIVITY IN EARLY RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB IN COMBINATION WITH METHOTREXATE: A SINGLE CENTER CROSS-SECTIONAL STUDY IN LANZHOU

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.7 Issue 6, pp 8-11,Year 2018

EVALUATION OF DISEASE ACTIVITY IN EARLY RHEUMATOID ARTHRITIS TREATED WITH TOCILIZUMAB IN COMBINATION WITH METHOTREXATE: A SINGLE CENTER CROSS-SECTIONAL STUDY IN LANZHOU

Manisha Bhochhibhoya, Rong Zhu, BinitVaidya, Md. Shahidur Khan, ShenHaili

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Received : 20 December 2018; Accepted : 11 January 2019 ; Published : 29 January 2019

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Article No. 10960
Abstract

In this study, we evaluate the clinical efficacy and safety of initial treatment by tocilizumab and methotrexate combination in moderate to severe cases of naive Rheumatoid Arthritis. American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) recommend Tocilizumabwith methotrexate combination or as a monotherapy in the management of RA if disease activity remains moderate or high despite the use of other drugs.Method: A retrospective chart review of a prospectively followed cohort of RA patients treated with tocilizumab and methotrexate was done from March 2016 to December 2018 in a tertiary center in Lanzhou. Result: Majority of patients were females (37/50; 74%), mean age at presentation was 36.3±14.7 years. All the parameters studied showed significant change with DAS28 ESR either at or below the low disease activity range (mean ±SD at 3.1±1.2).Conclusion: Combination of tocilizumab and methotrexate as initial treatment of early RA has significant improvement in disease activity.

Key Words   
Rheumatoid Arthritis, Tocilizumab, Disease Activity, Methotrexate, Interlukin-6

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To cite this article

Manisha Bhochhibhoya, Rong Zhu, BinitVaidya, Md. Shahidur Khan, ShenHaili , " Evaluation Of Disease Activity In Early Rheumatoid Arthritis Treated With Tocilizumab In Combination With Methotrexate: A Single Center Cross-sectional Study In Lanzhou ", International Journal of Latest Research in Science and Technology . Vol. 7, Issue 6, pp 8-11 , 2018

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