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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35,  Peer-reviewed, Open-access Journal

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EVALUATION OF SOME GENERIC DRUGS FOR REVERSAL OF MULTIDRUG-RESISTANCE IN PSEUDOMONAS AERUGINOSA USING COMPUTER-AIDED DRUG DESIGN

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.6 Issue 5, pp 60-66,Year 2017

EVALUATION OF SOME GENERIC DRUGS FOR REVERSAL OF MULTIDRUG-RESISTANCE IN PSEUDOMONAS AERUGINOSA USING COMPUTER-AIDED DRUG DESIGN

Adamu, Ahmed Adamu,Bello, shaibu Oricha,Chika, Aminu

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Received : 20 October 2017; Accepted : 28 October 2017 ; Published : 14 November 2017

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Abstract

The alarming rate of the increase in multidrug-resistant cases of Pseudomonas aeruginosa is a growing clinical issue necessitating the urgent need for new antibiotics and alternative strategies to combat the bacterial pathogen. Repurposing approved drugs in clinical use with known pharmacology and toxicology is one such cost-effective alternative approach. In this study, four essential protein targents for P. aeruginosa involved in the development of multidrug resistance were selected from Protein Data Bank using a validated method. Structure-based virtual screening method with PyRx was used to screen a database of 175 approved drugs. Celecoxib and meloxicam (marketed inhibitors of cyclooxygenase-2), fluconazole (an antifungal), desloratadine (antihistamine) and nitrofurantoin were found to bind with all the protein targets with binding energy greater than that obtained with the respective cocrystallized ligands.

Key Words   
P. aeruginosa,PyRx,multidrug-resistant, Molecular

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To cite this article

Adamu, Ahmed Adamu,Bello, shaibu Oricha,Chika, Aminu , " Evaluation Of Some Generic Drugs For Reversal Of Multidrug-resistance In Pseudomonas Aeruginosa Using Computer-aided Drug Design ", International Journal of Latest Research in Science and Technology . Vol. 6, Issue 5, pp 60-66 , 2017

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