Many Middle Eastern Universities are still struggling to establish themselves to achieve excellence in scientific research and education. The rising awareness in the science and technology, and implication of higher education in shaping future of the younger generation and building societies in the Middle Eastern region became inevitable in order to modify and upgrade educational policies and structure. The foremost step in this direction is governance that comes with hard decisions. The universities and national governments are willing to change strategic plans and institutional guidelines for the development of science and technology. King Abdulaziz University, Jeddah, Saudi Arabia is one of the few universities in the Middle East that rose to acquire the second rank among all the Arab and 351th among the world universities in 2014. King Abdulaziz University has tried to implement KPIs during previous strategic plan in order to achieve international distinction in scientific research and education. Introduction of KPIs helped university to grow but not as much as it was expected. The main reasons were occasional conflicts between KPIs and strategic plan of the university. The university now plans to synchronize KPIs with the current strategic plan that starts from 2016. In this paper, the authors have modified many existing KPIs and proposed others based on the university’s ideology, requirements and criteria. With its own KPIs the university will bring transparency, accountability and responsibility among its students, faculty and staff paving way to academic and scientific research development in order to be the role model for other universities in the region.