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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35,  Peer-reviewed, Open-access Journal

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Prognostic value of high DDX39 expression in esophageal squamous cell carcinoma

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.7 Issue 3, pp 19-23,Year 2018

PROGNOSTIC VALUE OF HIGH DDX39 EXPRESSION IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

JianXian Huang,JieCheng Ye,XueYun Zhong

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Received : 08 June 2018; Accepted : 16 June 2018 ; Published : 27 June 2018

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Article No. 10942
Abstract

Background: This study was aimed to validate a prognostic biomarker, adenosine triphosphate-dependent RNA helicase DDX39, in esophageal squamous cell carcinoma (ESCC). Novel prognostic biomarkers may help design more effective treatments for ESCC in the clinic. Methods: The expression level of DDX39 was bioinformatically detected and immunohistochemically examined in 95 ESCC cases. Correlation analyses were performed by χ2 test between DDX39 expression and clinicopathological parameters, and univariate analyses were performed to assess the prognostic value of DDX39 expression in ESCC. Results: Bioinformatics analysis showed DDX39 upregulated in esophageal cancer , while immunohistochemical study revealed that 61.1% of the 95 patients showed high DDX39 expression in ESCC tissues, and univariate analyses demonstrated that DDX39 expression was a prognostic factor in ESCC. Conclusions: These results established the clinical utility of DDX39 expression as a novel prognostic biomarker in ESCC, suggesting that DDX39 may be a potential therapeutic target for treating ESCC patients with elevated DDX39 expression.

Key Words   
Esophageal squamous cell carcinoma, DDX39, survival analysis

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To cite this article

JianXian Huang,JieCheng Ye,XueYun Zhong , " Prognostic Value Of High Ddx39 Expression In Esophageal Squamous Cell Carcinoma ", International Journal of Latest Research in Science and Technology . Vol. 7, Issue 3, pp 19-23 , 2018

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