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eISSN:2278-5299

International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35,  Peer-reviewed, Open-access Journal

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PARKINSON?S DISEASE GENE PRODUCT, PARKIN, HAS ALTERNATIVE AND REVERSIBLE FUNCTIONS, BOTH AS AN E3 LIGASE AND A REDOX MOLECULE.

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International Journal of Latest Research in Science and Technology Vol.5 Issue 4, pp 20-22,Year 2016

PARKINSON?S DISEASE GENE PRODUCT, PARKIN, HAS ALTERNATIVE AND REVERSIBLE FUNCTIONS, BOTH AS AN E3 LIGASE AND A REDOX MOLECULE.

Tohru Kitada , Rie Hikita, Hideo Hirose

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Received : 29 July 2016; Accepted : 07 August 2016 ; Published : 31 August 2016

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Article No. 10669
Abstract

We have recently shown that Parkin reacts with and reduces H2O2, a main component in mitochondrial oxidative stress, and forms Parkin dimer. In this in vitro study, we indicated that H2O2 leads to Parkin autoubiquitination as well as dimerization, and reduces E3 ligase activity in the ubiquitin-proteasome system. However, the antioxidant Dithiothreitol (DTT) decomposes polyubiquitinated Parkin dimers to the monomer level and reactivates Parkin’s E3 ligase activity, resulting in the increase of polyubiquitination of the substrate. Thus, Parkin protein has alternative and reversible functions as an E3 ligase and as a redox molecule to reduce oxidative stress. In other words, Parkin has a unique recycling system.

Key Words   
Parkin, Parkinson’s Disease, Mitochondria, Oxidative Stress, E3 Ligase, Ubiquitination, Pr

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References
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To cite this article

Tohru Kitada , Rie Hikita, Hideo Hirose , " Parkinson?s Disease Gene Product, Parkin, Has Alternative And Reversible Functions, Both As An E3 Ligase And A Redox Molecule. ", International Journal of Latest Research in Science and Technology . Vol. 5, Issue 4, pp 20-22 , 2016

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