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International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35,  Peer-reviewed, Open-access Journal

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EFFECTS OF OMEGA 3 AND VITAMIN E ON ANTIOXIDANT ENZYMES AND HSCRP IN CAD PATIENTS

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.5 Issue 3, pp 50-54,Year 2016

EFFECTS OF OMEGA 3 AND VITAMIN E ON ANTIOXIDANT ENZYMES AND HSCRP IN CAD PATIENTS

Somayeh Saboori,Mahmoud Djalali , Esmaeil Yousefi Rad,Atena Ramezani,Fariba Koohdani, Ebrahim Nematipour

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Received : 17 June 2016; Accepted : 22 June 2016 ; Published : 30 June 2016

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Article No. 10664
Abstract

Inflammation, as a consequence of oxidative stress, is a key factor in development of cardiovascular diseases. The aim of the current study was to assess the effects of omega 3 and vitamin E supplementation on the serum level of antioxidant enzymes and hsCRP levels in CAD patients. Participants of this RC T study included 60 non-smoker male CAD patients who received 4g/day of omega 3 and vitamin E placebo (OP), omega 3 (4g/day) and 400IU/day vitamin E (OE) or omega 3 and vitamin E placebos (PP) for two months. Serum antioxidant enzymes and hsCRP levels were measured at the baseline and at the end of the study and effects of the intervention on these parameters were compared between and within the groups. Serum levels of catalase increased significantly in OE and OP groups (P=0.002 and P= 0.015, respectively). TAC increased significantly in OE group (P=0.009) but not in OP and PP groups. Serum SOD and GPX did not change significantly in any of the groups or between the groups. Omega 3 alone and combined omega 3 and vitamin E supplementations decreased hsCRP significantly in OP and OE groups (P=0.008 and P= 0.050, respectively).Co-administration of omega 3 and vitamin E in CAD patients seems to include beneficial effects on inflammation by decreasing hsCRP levels and to improve oxidative stress by influencing antioxidant enzymes.

Key Words   
CAD, omega 3, vitamin E, antioxidant enzyme, hsCRP

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To cite this article

Somayeh Saboori,Mahmoud Djalali , Esmaeil Yousefi Rad,Atena Ramezani,Fariba Koohdani, Ebrahim Nematipour , " Effects Of Omega 3 And Vitamin E On Antioxidant Enzymes And Hscrp In Cad Patients ", International Journal of Latest Research in Science and Technology . Vol. 5, Issue 3, pp 50-54 , 2016

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