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International Journal of Latest Research in Science and Technology

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PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF MELIACEAE AND Azadirachta indica A. JUSS.

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.4 Issue 4, pp 128-135,Year 2015

PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF MELIACEAE AND AZADIRACHTA INDICA A. JUSS.

Denise Porfirio Emerenciano, Maria Aparecida Medeiros Maciel, Francisco Humberto Xavier Júnior, Maria de Fátima Vitória de Moura

Correspondence should be addressed to :

Received : 26 August 2015; Accepted : 29 August 2015 ; Published : 31 August 2015

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Abstract

The use of medicinal plants by world’s population owns a large medical history keeping the interest on natural products research. In this context, Azadirachta indica A. Juss (Meliaceae), popularly known as neem, is widely used in folk medicine due its numerous therapeutic properties. From this plant a limonoid tetranortriterpenoid, azadirachtin, has been linked to several biological activities. Additionally, this compound shows significant importance over ecological aspects including insect pests control and also repellent, antifeedant and insecticidal effects. Current analysis on ethnopharmacologic, chemical and phytopharmacological of medicinal plants focusing upon Azadirachta indica A. Juss. species.

Key Words   
Meliaceae; Azadirachta indica A. Juss.; Azadirachtin; Ethnobotany; Phytochemistry;

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References
  1. M. Klein, “Meliáceas: Flora Ilustrada Catarinense”, Itajaí, Parte I, pp. 138, 1984.
  2. P. Matos, “Busca de compostos inseticidas: estudo de espécies do gênero Trichilia (Meliaceae)”, PhD degree in Programa de Pós-Graduação em Química. Federal University of São Carlos - UFSCar, Center of Exact Sciences and Technology, Department of Chemistry, São Carlos, 194 f., 2006.
  3. D. Morgan, “Azadirachtin, a scientific gold mine”, Bioorganic & Medicinal Chemistry, v. 17, pp. 4096-4105, 2009.
  4. Johnson, E. D. Morgan and C. C. Peiris, “Development of the Major Triterpenoids and Oil in the Fruit and Seeds of Neem (Azadirachta indica)”, Annals of Botany: Oxford Journals, v. 78, pp. 383-388, 1996.
  5. M. O. Simões, E. P. Schenkel, G. Gosmann, J. C. P. Mello, L. A. Mentez and P. R. Petrovick, “Farmacognosia: da planta ao medicamento”. 6. edition. Porto Alegre/Florianópolis, Editora da UFRGS, pp. 903-918, 2010.
  6. S. Martinez, “Nim”, Revista DBO, v. 26, n. 324, 2007.
  7. Nicoletti, O. Maccioni, T. Coccioletti, S. Mariani and F. Vitali, “Neem Tree (Azadirachta indica A. Juss) as Source of Bioinsectides”, Inseticides: Advances in Integrated Pest Management, pp. 411-428, 2012.
  8. Ermel, E. Pahlich and H. Schmutterer, “Azadirachtin content of Neem kernels from different geographical locations, and its dependence on temperature, relative humidity, and light”, In: H. Schmutterer, K. R. S. Ascher, (eds.). Natural pesticides from the Neem tree and other tropical plants. Proceedings of the 3º International Neem Conference Nairobi, Kenya. GTZ, Eschbom, pp. 171-184, 1987.
  9. S. Djenontin, V. D. Wotto, F. Avlessi, P. Lozano, D. K. C. Sohounhloué and D. Pioch, “Composition of Azadirachta indica and Carapa procera (Meliaceae) seed oils and cakes obtained after oil extraction”, Industrial Crops and Products, v. 38, pp. 39-45, 2012.
  10. G. Soon and D. G. Bottrell, “Neem pesticides in rice: potencial and limitations”, Manila, IRRI - International Rice Research Institute, v. 64, 1994.
  11. A. M. Maciel, A. C. Pinto, V. F. Veiga-Junior, N. F. Grynberg and A. Echevarria, “Medicinal Plants: the need for multidisciplinary scientific studies”, Química Nova, v. 25, n. 3, pp. 429-438, 2002.
  12. WHO, General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine World Health Organization, Geneva, 2000.
  13. C. Viegas, V. S. Bolzani, and E. J. Barreiro, “The natural products and the modern medicinal chemistry”, Química Nova, v. 29, n. 2, pp. 326-337, 2006.
  14. A. M. Maciel, F. E. S. Gomes, B. A. Soares, N. F. Grynberg, A. Echevarria, I. M. S. Cólus, C. Kaiser, W. A. Morais and N. S. S. Magalhães, “Biological effectiveness and recent advancing of natural products on the discovery of anticancer agents”, In: Bioactive Phytochemicals: Perspectives for Modern Medicine, Nova Delhi: Daya Pulishing House, v. 2, chapter 12, p. 239-293, 2014.
  15. M. K. Rates, “Plants as source of drugs”, Toxicon, v. 39, pp. 603-613, 2001.
  16. A. C. Araújo, M. F. S. Teixeira, T. V. M. Dantas, V. S. P. Melo, F. E. S. Lima, A. R. F. Ricarte, E. C. Costa and A. M. Miranda, “Usos potenciais de Melia azedarach L. (meliaceae): um levantamento”, Arquivos do Instituto Biológico, v. 76, n. 1, pp. 141-148, 2009.
  17. S. Garcia. “Biodiversidade, Biotecnologia e Saúde”. Cadernos deSaúde Pública, v. 11, n. 3, pp. 491-494, 1995.
  18. C. França, “Abordagens Biotecnológicas para a Obtenção de Substâncias Ativas”, In: C. M. O. Simões, E. P. Schenkel, G. Gosmann, J. C. P. Mello, L. A. Mentez and P. R. Petrovick, “Farmacognosia: da planta ao medicamento”, 6. edition, Porto Alegre/Florianópolis, Editora da UFRGS, pp. 903-918, 2010.
  19. M. Albuquerque, “Plantas Medicinais de Uso popular”, ABEAS/ MEC. Programa Agricultura nos Trópicos, Brasília, v. 6, pp. 96, 1989.
  20. Y. Agredo, “Introdución a la etnobotánica colombiana”, Sociedad Colombiana de Etnologia, v. 1, pp. 1-48, 1953.
  21. R. Cardona, “La Foresta di Piume: Manuale di Etnoscienza”, Roma, Laterza, p. 193, 1985.
  22. G. Brunhn and B. Holmstedt, “Ethnopharmacology: objetives, principles and perspectives”,In: J. L. Beal, and E. Reinhard, (Ed.), “Natural products as medicinal agentes”, Suplemment Planta Medica, Journal of Medical Plants Research and Journal of Natural Products, p. 526, 1980.
  23. A. H. Taylor, “The chemistry of the limonoids from Meliaceae. In: Progress in the Chemistry of Organic Natural Products”, W. Herz, H. Grisebach, G. W. Kirby (Eds.). Springer, New York, pp. 1-102, 1984.
  24. V. Maciel, S. M. Morais, C. M. L. Bevilaqua and S. S. A. Amóra, “Extratos vegetais usados no controle de dípteros vetores de zoonoses”, Revista Brasileira de Plantas Medicinais, v.12, n. 1, 2010.
  25. P. Matos, L. Nebo, P. C. Vieira, J. B. Fernandes, M. F. G. F. Silva and R. R. Rodrigues, “Constituintes Químicos e Atividade Inseticida dos Extratos de Frutos de Trichilia elegans e T. catigua (Meliaceae)”, Química Nova, v. 32, n. 6, pp. 1553-1556, 2009.
  26. IAPAR - Instituto Agronômico do Paraná. O Nim - Azadirachta indica - um Inseticida Natural. Available in: . Access in: 25 Mar. 2015.
  27. S. Martinez, J. Lima and A. L. Boiça-Junior, “Avaliação agronômica e fitoquímica de Neem, Azadirachta indica de diferentes procedências em vários locais das regiões Sul e Sudeste do Brasil”, XVII Congresso Brasileiro de Entomologia. Sociedade Entomológica do Brazil, Abstracts, pp. 831, 1998.
  28. D. Luo, S. H. Wu, Y.B. Ma and D. G. Wu, “A new triterpenoid from Azadirachta indica”, Fitoterapia, v. 71, pp. 668-672, 2000.
  29. H. Butterworth and E. D. Morgan, “Investigation of the locust feeding inhibition of the seeds of the Neem tree, Azadirachta indica”, Journal of Insect Physiology, v. 17, n. 6, pp. 969-977, 1971.
  30. R. Zanno, I. Minra and K. Nakanishi, “Structure of the insect phagorepellent azadirachtin. Application of PRFT/CWD Carbon-13 Nuclear Magnetic Resonance”, Journal of Insect Physiology, v. 97, n. 7, pp. 1975-1977, 1975.
  31. Kraus, M. Bokel, A. Klenk and H. Pöhnl, “Structure determination by NMR of azadirachtin and related compounds from Azadirachta indica A. Juss (Meliaceae)”, TetrahedronLetters, v. 43, n. 12, pp. 2817-2830, 1987.
  32. P. Neves, I. P. Oliveira and J. C. M. Nogueira, “Cultivo e Utilização do Nim Indiano”, EMBRAPA Circular Técnica 62, Santo Antônio de Goiás, Goiás, Brazil, 2003.
  33. A. G. Mossini and C. Kemmelmeier. “A árvore Nim (Azadirachta indica A, Juss): Múltiplos Usos”. Acta Farmaceutica Bonaerense, v. 24, n. 1, pp. 139-48, 2005.
  34. G. Hedge, “Improving the producivity of Neem trees. World Neem Conference”, Indian Journal of Entomology, v. 50, pp. 147-150, 1993.
  35. J. Boeke, M. G. Boersma, G. M. Alink, J. J. A. V. Loon, A. V. Huis, M. Dicke and I. M. C. M. Rietjens, “Safety Evaluation of Neem (Azadirachta indica) Derived Pesticides”, Journal of Ethnopharmacology, v. 94, pp. 25-41, 2004.
  36. Deng, M. Cao, D. Shi, Z. Yin, R. Jia, J. Xu, C. Wang, C. Lv, X. Liang, C. He, Z. Yang and J. Zhao, “Toxicological Evaluation of Neem (Azadirachta indica) Oil: Acute and Subacute Toxicity”, Environmental Toxicology and Pharmacology, v. 35, n. 2, pp. 240-246, 2013.
  37. R. Coats, “Risks fron natural versus synthetic insecticides”, Annual Review of Entomology, v. 39, pp. 489-515, 1994.
  38. Bibi, S. Nisa, M. Zia, A. Waheed, S. Ahmed and M.F. Chaudhary, “In vitro cytotoxic activity of Aesculus indica against breast adenocarcinoma cell line (MCF-7) and phytochemical analysis”, Pakistan Journal of Pharmaceutical Sciences, v. 25, n. 1, pp. 183-187, 2012.
  39. Tariq, S. Mussarat and M. Adnan, “Review on ethnomedicinal, phytochemical and pharmacological evidence of Himalayan anticancer plants”, Journal of Ethnopharmacology, 64, n. 22, pp. 96-119, 2015.
  40. Y. Ragasa, Z. D. Nacpil, G. M. Natividad, M. Tada, J. C. Coll and J. A. Rideout, “Tetranortriterpenoids from Azadirachta indica”, Phytochemistry, v. 46, n. 3, pp. 555-558, 1997.
  41. Paritala, K. K. Chiruvella, C. Thammineni, R. G. Ghanta and A. Mohammed, “Phytochemicals and antimicrobial potentials of mahogany family”, Revista Brasileira de Farmacognosia, v. 25, n. 1, pp. 61-83, 2015.
  42. S. Siddiqui, F. Afshan, T. Gulzar and M. Hanif, “Tetracyclic triterpenoids from the leaves of Azadirachta indica”, Phytochemistry, v. 65, pp. 2363-2367, 2004.
  43. R. Govindachari, R. Malathi, G. Gopalakrishnan, G. Suresh and S. S. Rajan, “Isolation of a new tetranortriterpenoid from the uncrushed green leaves of Azadirachta indica”, Phytochemistry, v. 52, pp. 1117-1119, 1999.
  44. C. T. Silva, G. N. Jham, R. D. L. Oliveira and L. Brown, “Purification of the seven tetranortriterpenoids in Neem (Azadirachta indica) seed by counter-current chromatography sequentially followed by isocratic preparative reversed-phase high-performance liquid chromatography”, Journal of Chromatography A, v. 1151, pp. 203-210, 2007.
  45. Melwita and Y-H. Ju, “Separation of azadirachtin and other limonoids from crude Neem oil via solvent precipitation”, Separation and Purification Technology, v. 74, pp. 219-224, 2010.
  46. R. Schroeder and K. Nakanishi, “A simplified isolation procedure for azadirachtin”, Journal of Natural Products, v. 50, pp. 241-244, 1987.
  47. P. Jarvis, E. D. Morgan and C. Edwards, “Rapid separation of triterpenoids from Neem seed extracts”. Phytochemistry Analysis, v. 10, pp. 39-43, 1999.
  48. Sharma, S. Walia, J. Kumar, M. G. Nair and B. S. Parmar, “An efficient method for the purification and characterization of nematicidal azadirachtins A, B, and H, using MPLC and ESIMS”, Journal of Agricultural and Food Chemistry, pp. 3966-4397, 2003.
  49. Bhatia, Y. P. Sharma, R. K. Manhas and K. Kumar, “Traditional phytoremedies for the treatment of menstrual disorders in district Udhampur”, Journal of Ethnopharmacology, v. 160, pp. 202-210, 2015.
  50. Xu, Qiao-Jia Fan, Zhong-Q. Yin, Xu-T. Li, Yong-H. Du, Ren-Y. Jia, Kai-Y. Wang, C. Lv, G. Ye, Y. Geng, G. Su, L. Zhao, Ting-X. Hu, F. Shi, L. Zhang, Chang-L. Wu, C. Tao, Ya-X. Zhang, Dong-X. Shi, “The preparation of neem oil microemulsion (Azadirachta indica) and the comparison of acaricidal time between neem oil microemulsion and other formulations in vitro”, Veterinary Parasitology, n. 169, pp. 399–403, 2010.
  51. J. Ahmed and G. Murtaza, “A study of medicinal plants used as ethnoveterinary: Harnessing potential phytotherapy in Bheri, District Muzaffarabad (Pakistan)”, Journal of Ethnopharmacology, v. 159, pp. 209-214, 2015.
  52. Singh, N. K. Kaushik, D. Mohanakrishnan, S. K. Tiwari and D. Sahal. “Antiplasmodial activity of medicinal plants from Chhotanagpur plateau, Jharkhand, India”. Journal of Ethnopharmacology, v. 165, pp. 152-162, 2015.
  53. Farzaneh and I. S. Carvalho, “A review of the health benefit potentials of herbal plant infusions and their mechanism of actions”, Industrial Crops and Products, v. 65, pp. 247-258, 2015.
  54. U. Rehmana, A. Alia, I. A. Khana, “Plant based products: Use and development as repellents against mosquitoes: A review”, Fitoterapia, v. 95, pp. 65–74, 2014.
  55. E. Magrini, A. Specht, J. Gaio, C. P. Girelli, I. Migues, H. Heinzen, J. Saldaña, V. C. Sartori and V. Cesio, “Antifeedant activity and effects of fruits and seeds extracts of Cabralea canjerana canjerana (Vell.) Mart. (Meliaceae) on the immature stages of the fall armyworm Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae)”, Industrial Crops and Products, v. 65, p. 150-158, 2015.
  56. L. Kashyapa, X. Xiang, P. Heidenb, “Chitosan nanoparticle based delivery systems for sustainable agriculture”, International Journal of Biological Macromolecules, v. 77, pp. 36–51, 2015.
  57. L. Camara, M. C. Silva, M. C. P. Costa and P. E. S. Marinho, “Processo de preparo e aplicação de compostos inseticidas obtidos a partir do extrato hidroalcoólico do nim (Azadirachta indica A. Juss) para eliminação de ovos e larvas do Aedes aegypti”, Patent PI 10038922A2, 2012.
  58. Joice P., R. Parthasarathi, “Development and Evaluation of Antimicrobial Wound Dressings Impregnated with Herbal Nanocapsules”, International Journal of Applied Microbiology Science, v. 1, n. 3, pp. 35-41, 2012.
  59. P. Emerenciano, C. G. F. T. Rossi, T. N. C. Dantas, M. F. V. Moura and M. A. M. Maciel, “Obtenção de Sistemas Nanoautoemulsificantes Utilizando Óleo das Sementes de Azadirachta indica A. Juss para Aplicação como Inibidor de Corrosão”, Patent BR 1020140228756, 2014.

 

To cite this article

Denise Porfirio Emerenciano, Maria Aparecida Medeiros Maciel, Francisco Humberto Xavier Júnior, Maria de Fátima Vitória de Moura , " Phytochemical And Pharmacological Aspects Of Meliaceae And Azadirachta Indica A. Juss. ", International Journal of Latest Research in Science and Technology . Vol. 4, Issue 4, pp 128-135 , 2015

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