Sign In
Register
eISSN:2278-5299

International Journal of Latest Research in Science and Technology

DOI:10.29111/ijlrst   ISRA Impact Factor:3.35,  Peer-reviewed, Open-access Journal

A News Letter Sign UP!
COULD GRAPE SEED EXTRACT MODULATES NEPHRITIC DAMAGE INDUCED BY METHOMEX IN MALE RATS?

Research Paper Open Access

International Journal of Latest Research in Science and Technology Vol.2 Issue 5, pp 26-31,Year 2013

COULD GRAPE SEED EXTRACT MODULATES NEPHRITIC DAMAGE INDUCED BY METHOMEX IN MALE RATS?

Amal Attia El-Morsy Ibrahim

Correspondence should be addressed to :

Received : 22 October 2013; Accepted : 27 October 2013 ; Published : 31 October 2013

Share
Download 125
View 180
Article No. 10201
Abstract

Methomex (Metho) is classified as a carbamate insecticide. The present study was designed to examine the influence of grape seed oil (GSO) on the histopathological changes in Methomex-induced kidney in male rats. Rats were divided into 6 groups, the first of which was considered as control. The 2nd group was treated with 4 ml/kgGSO. Rats from 3rd and 4th groups treated with Metho at level doses 2.4 mg/kg and 4.8 mg/kg. Rats from 5th and 6th groups pre-administered with GSO then treated with 2.4 and 4.8 mg/kg Metho. Metho administration caused destruction of the normal pattern of the renal tissue. These damages were encountered by the presence some glomeruli appeared atrophy with distension of Bowman’s space and degeneration of their parietal epithelial cells. The lumina of distal and proximal convoluted tubules contain hyaline casts of dead cells. The renal medulla showed dilated collecting tubules stuffed with R.B.Cs. Pre-administration of GSO to Metho-induced rats, revealed apparent normal renal parenchyma. The proximal convoluted tubules and collecting tubules appeared near to normal with their narrow lumen. Pre-administration with GSO exhibited that it has a protective effect against Methomex-induced toxic effects in the kidney. The present study advocated using GSO in the daily diets.

Key Words   
Grape seed oil - Methomex – Kidney - Histopathology

Copyright
References
  1. Ashtiyani SC, Najafi H, Firouzifar MR, Shafaat O (2013). Grape seed extract for reduction of renal disturbances following reperfusion in rats. Iran. J. Kid. Diseas. 7(1): 28-35.
  2. Baiges I, Palmfeldt J, Bladãc C, Gregersen N, Arola L (2010). Lipogenesis is decreased by grape seed proanthocyanidins according to liver proteomics of rats fed a high fat diet. Mol. Cell Proteomics. 9(7): 1499-1513.
  3. Çetin A, Kaynar L, Kocyigit I, Hacioglu SK, Saraymen R, Öztürk A, Orhan O, Sagdiç O (2008). The effect of grape seed extract on radiation-induced oxidative stress in the rat liver. Turk. J. Gastroenterol. 19(2): 92-98
  4. Dulundu E, Ozel Y, Topaloglu U, Toklu H, Ercan F, Gedik N, Sener G (2007). Grape seed extract reduces oxidative stress and fibrosis in experimental biliary obstruction. J. Gastroenterol. Hepatol. 22: 885-892.
  5. El-Ashmawy IM, Saleh A, Salama OM (2007). Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats. Basic Clin. Pharmacol. Toxicol. 101(5): 320-327.
  6. El-Fakharany II, Massoud AH, Derbalah AS, SaadAllah MS (2011). Toxicological effects of methomyl and remediation technologies of its residues in an aquatic system. J. Environment. Chem. Ecotoxicol. 3(13): 332-339.
  7. El-Khawaga OA (2005). Role of selenium on antioxidant capacity in methomyl-treated mice. J. Physiol. Biochem. 61(4): 501-506.
  8. EPA, 1987, US Environmental Protection Agency (1987). Health Advisory Summary. Methomyl. Washington, DC, pp. 3-40, http://www. epa.gov/iris/subst/0069.htm (12 November 2008 date last accessed).
  9. Farré M, Fernandez J, Paez M, Granada L, Barba L, Gutierrez HM, Pulgarin C, Barceló D (2002). Analysis and toxicity of methomyl and ametryn after biodegradation. Analytic. Bioanalytic. Chem. 373: 704-709.
  10. Fayez V, Bahig MR (1992). Short term toxicity of methomyl in rats. Chemosphere 23: 375-381.
  11. Finn WF (1977). Renal responses to environmental toxins. Environ. Health Perspect. 20: 15-26.
  12. Humason GL (1979). Animal Tissues. 4th ed., W.H. Freeman and Company, San Fransisco.
  13. Ibitayo OO (2006). Egyptian farmers' attitudes and behaviors regarding agricultural pesticides: implications for pesticide risk communication. Risk Analysis, 26: 989-995.
  14. Laurent G, Toubeau G, Heuson-Steinnon JA, Tulkens P, Maldauge P (1988). Kidney tissue repair after nephrotoxic injury:biochemical and morphologic characterization. CRC Crit. Rev. Toxicol. 19: 147-183.
  15. Maheswari UM, Rao PG (2005). Antihepatotoxic effect of grape seed oil in rats. Ind. J. Pharmacol. 37 (3): 179-182.
  16. Mahgoub AA, El-Medany AH (2001). Evaluation of chronic exposure of the male rat reproductive system to the insecticide methomyl. Pharmacol. Res. 44(2): 73-80.
  17. Mansour SA, Mossa AT, Heikal TM (2009). Effects of methomyl on lipid peroxidation and antioxidant enzymes in rat erythrocytes: in vitro studies. Toxicol. Ind. Health 25(8): 557-563.
  18. Nariman AR, Ahmed AR, Amira HM, Dessouky MI (1995). Serum biochemical and histopathological changes associated with repeated exposure of rats to Thiodicarb insecticide. Egypt. J. Comp. Pathol. Clin. Pathol. 8: 79-85.
  19. Pinheiro FV, Pimentel VC, De Bona KS, Scola G, Salvador M, Funchal C, Moretto MB (2010). Decrease of adenosine deaminase activity and increase of the lipid peroxidation after acute methotrexate treatment in young rats: protective effects of grape seed extract. Cell Biochem. Funct. 28(1):89-94.
  20. Puiggrãs F, Sala E, Vaquã M, Ardãcvol A, Blay M, Fernã¡ndez-Larrea J, Arola L, Bladãc C, Pujadas G, Salvadã MJ (2009). In vivo, in vitro, and in silico studies of Cu/Zn-superoxide dismutase regulation by molecules in grape seed procyanidin extract. J. Agric. Food Chem. 57(9): 3934-3942.
  21. Radad K, Hashim A, EL-Sharqawy EEG, Youssef MSE (2009). Histopathological effects of methomyl on sprague-dawley rats after repeated application. Bulg. J. Veter. Med. 12(2): 149-157
  22. Sehirli O, Ozel Y, Dulundu E, Topaloglu U, Ercan F, Sener G (2008). Grape seed extract treatment reduces hepatic ischemia-reperfusion injury in rats. Phytother. Res. 22(1): 43-48.
  23. Selmanoglu G, Barlas N, Songür S, Koçkaya EA (2001). Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats. Human Exper. Toxicol. 20: 625-630.
  24. Shin MO, Yoon S, Moon JO (2010). The proanthocyanidins inhibit dimethylnitrosamine-induced liver damage in rats. Arch. Pharm. Res. 33(1): 167-173.
  25. Thomson WT (1992). Official of pesticide programs. USA.EPA. Washington, DC. (72) Agri. Chem. Handbook, Book 1.Themson Pub. Fresno, CA.
  26. WHO (1996). Environmental health criteria; Methomyl insecticide. World Health Organization, Geneva, pp. 1-96. http://www. inchem.org/documents/ehc/ehc/ehc178.htm (12 November 2008 date last accessed).
To cite this article

Amal Attia El-Morsy Ibrahim , " Could Grape Seed Extract Modulates Nephritic Damage Induced By Methomex In Male Rats? ", International Journal of Latest Research in Science and Technology . Vol. 2, Issue 5, pp 26-31 , 2013

Responsive image

MNK Publication was founded in 2012 to upholder revolutionary ideas that would advance the research and practice of business and management. Today, we comply with to advance fresh thinking in latest scientific fields where we think we can make a real difference and growth now also including medical and social care, education,management and engineering.

Responsive image

We offers several opportunities for partnership and tie-up with individual, corporate and organizational level. We are working on the open access platform. Editors, authors, readers, librarians and conference organizer can work together. We are giving open opportunities to all. Our team is always willing to work and collaborate to promote open access publication.

Responsive image

Our Journals provide one of the strongest International open access platform for research communities. Our conference proceeding services provide conference organizers a privileged platform for publishing extended conference papers as journal publications. It is deliberated to disseminate scientific research and to establish long term International collaborations and partnerships with academic communities and conference organizers.